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Chiral diphosphites and diphosphoramidites derived from BINOL or diphenylprolinol are efficient ligands in asymmetric Rh-catalyzed olefin hydrogenation, provided the proper achiral backbone is chosen.

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Apr 11, 2019 · Hydrogen-deuterium exchange mass spectrometry is applied to probe the conformational dynamics of human SERT in the absence and presence of known substrates and targeted drugs to provide a comprehensive direct view of the conformations of SERT upon binding both biologically relevant substrate/ions and ligands of pharmaceutical …

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